Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels
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چکیده
منابع مشابه
Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels.
Potassium channels that are inhibited by internal ATP (K(ATP) channels) provide a critical link between metabolism and cellular excitability. Protein kinase C (PKC) acts on K(ATP) channels to regulate diverse cellular processes, including cardioprotection by ischemic preconditioning and pancreatic insulin secretion. PKC action decreases the Hill coefficient of ATP binding to cardiac K(ATP) chan...
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The Department of Biomedical Science, The University, Western Bank, Sheffield. S10 2TN. patches. However, when exactly the same protocol was carried out cn patches of membrane excised from cells pre-treated overnight with 1 M PMA, pdymyxin-B induced Mock was readily reversible (n=8). There is therefore a marked difference in the mechanism of action of polymyxin B on K+AW channels in the presenc...
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Recent studies have shown that intracerebroventricular administration of cimetidine (CIM) induces anti-nociceptive and anti–inflammatory effects in rats. However, the underlying mechanism of CIM effect has not been determined yet. This study was planned to determine the anti-nociceptive effect of CIM (50 mg/kg, i.p.) in male mice (25-30 g, n = 80) using tail flick test. Also, the role of ATP-se...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2000
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.160068997